The Use of Raman Spectroscopy in the Study of Mixing Mechanisms for Powder Blends

Authors

  • P. Doležel Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno
  • J. Muselík Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno

Keywords:

Raman spectroscopy, mixing mechanisms, powder mixtures, multidimensional data analysis, process analytical technology

Abstract

The article describes the development of calibration procedures for quantitative evaluation of powder blends utilizing non-contact probe of Raman spectrometer. Two model blends containing ascorbic acid and lactose were chosen. They differed in the used sieve fractions. A new procedure combining convective-diffusive and shear mixing was used for the development of PLS (partial least squares regression) calibration methods. This procedure significantly improves the homogeneity of the mixtures containing fine particles of the size below 100 µm. The newly developed methods were further utilized to study blending and the impact of vibrations on the powder blend. The results imply that the particles size has a statistically significant impact on the change of homogeneity in the course of vibration action. The results demonstrated the potential of Raman spectroscopy to be used as a PAT (process analytical technology) method in pharmaceutical analysis.

Published

2014-02-15

How to Cite

Doležel, P., & Muselík, J. (2014). The Use of Raman Spectroscopy in the Study of Mixing Mechanisms for Powder Blends. Chemické Listy, 108(2), 167–171. Retrieved from http://www-.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/558

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Articles

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